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Search Results for " dna alkylator/crosslinker "

20

Compounds

Cat No. Product Name Synonyms Targets
T0707L Cyclophosphamide DNA Alkylator/Crosslinker , DNA , MRP
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T4368 Miriplatin SM-11355 DNA Alkylator/Crosslinker
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T1564 Cisplatin cis-Diaminodichloroplatinum,CDDP DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T0164 Oxaliplatin L-OHP DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autop...
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T0923 Busulfan Myleran,Sulphabutin,Busulphan Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation...
T15793 Lurbinectedin PM01183 Others
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
T5017 Nimustine Hydrochloride Nidran hydrochloride Apoptosis , Others , DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
T1058 Carboplatin NSC 241240,CBDCA,JM-8 DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.
T1055 Ifosfamide NSC109724,Isophosphamide DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...
T8380 Bendamustine SDX105 Apoptosis , Others , DNA Alkylator/Crosslinker
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T8554 KCC-07 DNA Alkylator/Crosslinker
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes...
T0975 Chlorambucil CB-1348,Chloroambucil,WR-139013 DNA Alkylator/Crosslinker , DNA Alkylation
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...
T17159 Treosulfan NSC 39069,Treosulphan DNA Alkylator/Crosslinker , DNA Alkylation
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T1601 Lomustine CCNU,NSC 79037 Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T4558 Trioxsalen Trimethylpsoralen,Trioxysalen,Trisoralen DNA Alkylator/Crosslinker , DHFR
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...
T1798 RITA NSC 652287,RITA (NSC 652287) Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
T0707 Cyclophosphamide hydrate Cyclophosphamide monohydrate DNA Alkylator/Crosslinker , DNA , MRP
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
T3091 Carmustine bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris DNA Alkylator/Crosslinker , DNA Alkylation
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T1250 Thio-TEPA Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid DNA Alkylator/Crosslinker , DNA Alkylation , Antibacterial , Antibiotic
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.

Compounds

Cyclophosphamide
T0707L
Synonym:
Target: DNA Alkylator/Crosslinker, DNA, MRP
Miriplatin
T4368
Synonym: SM-11355
Target: DNA Alkylator/Crosslinker
Cisplatin
T1564
Synonym: cis-Diaminodichloroplatinum,CDDP
Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy
Oxaliplatin
T0164
Synonym: L-OHP
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Duocarmycin TM
T11120
Synonym:
Target: DNA Alkylation, Antibiotic
Busulfan
T0923
Synonym: Myleran,Sulphabutin,Busulphan
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA Alkylation
Lurbinectedin
T15793
Synonym: PM01183
Target: Others
Nimustine Hydrochloride
T5017
Synonym: Nidran hydrochloride
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Carboplatin
T1058
Synonym: NSC 241240,CBDCA,JM-8
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Ifosfamide
T1055
Synonym: NSC109724,Isophosphamide
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Bendamustine
T8380
Synonym: SDX105
Target: Apoptosis, Others, DNA Alkylator/Crosslinker
KCC-07
T8554
Synonym:
Target: DNA Alkylator/Crosslinker
Chlorambucil
T0975
Synonym: CB-1348,Chloroambucil,WR-139013
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Treosulfan
T17159
Synonym: NSC 39069,Treosulphan
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Lomustine
T1601
Synonym: CCNU,NSC 79037
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy
Trioxsalen
T4558
Synonym: Trimethylpsoralen,Trioxysalen,Trisoralen
Target: DNA Alkylator/Crosslinker, DHFR
RITA
T1798
Synonym: NSC 652287,RITA (NSC 652287)
Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy
Cyclophosphamide hydrate
T0707
Synonym: Cyclophosphamide monohydrate
Target: DNA Alkylator/Crosslinker, DNA, MRP
Carmustine
T3091
Synonym: bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Thio-TEPA
T1250
Synonym: Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid
Target: DNA Alkylator/Crosslinker, DNA Alkylation, Antibacterial, Antibiotic
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TargetMol